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Center for Basics in NeuroModulation
Center for Basics in NeuroModulation
Center for Basics in NeuroModulation
Center for Basics in NeuroModulation

Welcome to the Center for Basics in NeuroModulation

The Center for Basics in NeuroModulation (NeuroModulBasics) is an initiative of neuroscience researchers based in Freiburg to connect experts in neurosciences and, thus, strengthen the local research network. In the form of a “virtual center”, it supports neuroscience research to understand complex brain function from basic research to clinically relevant settings by joining interdisciplinary expertises and methods to create new ideas and concepts. NeuroModulBasics aims to decipher the mechanisms of how intrinsic and extrinsic factors modulate brain function and the risk for and resilience against CNS pertubations, in order to better understand how neuromodulatory treatments such as pharmacological and psychotherapeutic interventions or (non)-invasive brain stimulation confer their effects on molecular, cellular and system levels.

Research Program

Publications

Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A: Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity 54(4):648-659.e8; doi: 10.1016/j.immuni.2021.02.004 (2021).

Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT: Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19. Brain awab009; doi: 10.1093/brain/awab009 (2021).

Lenz M, Kruse P, Eichler A, Straehle J, Beck J, Deller T, Vlachos A: All-trans retinoic acid induces synaptic plasticity in human cortical neurons. Elife 10:e63026; doi: 10.7554/eLife.63026 (2021).

Turi Z, Lenz M, Paulus W, Mittner M, Vlachos A: Selecting stimulation intensity in repetitive transcranial magnetic stimulation studies: A systematic review between 1991 and 2020. Eur J Neurosci; doi: 10.1111/ejn.15195 (2021).

Emig RWiebke Knodt W, Krussig MJ, Zgierski-Johnston  CM, Gorka O, Groß O, Kohl P, Ravens U, Peyronnet R: Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing. Cells 10(3):663; doi: 10.3390/cells10030663 (2021).

Turi Z, Normann C, Domschke K, Vlachos A: Transcranial Magnetic Stimulation in Psychiatry: Is There a Need for Electric Field Standardization? Front Hum Neurosci 15:639640; doi: 10.3389/fnhum.2021.639640, eCollection (2021).

Lenz M, Eichler A, Vlachos A: Monitoring and Modulating Inflammation-Associated Alterations in Synaptic Plasticity: Role of Brain Stimulation and the Blood-Brain Interface.Biomolecules 11(3):359; doi: 10.3390/biom11030359 (2021).

Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C and Simons M: Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nature Metabolism 3, 211–227 (2021).

Hildebrandt-Einfeldt L, Yap K, Paul MH, Stoffer C, Zahn N, Alexander Drakew A, Lenz M, Vlachos A, Deller T: Crossed Entorhino-Dentate Projections Form and Terminate With Correct Layer-Specificity in Organotypic Slice Cultures of the Mouse Hippocampus. Front Neuroanat 15:637036; doi: 10.3389/fnana.2021.637036. eCollection (2021).

Kandadai KS, Kotur MB, Dokalis N, Amrein I, Keller CW, Münz C, Wolfer D, Prinz M and Lünemann JD: ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice. Autophagy 1-11; https://doi.org/10.1080/15548627.2021.1883880 (2021).

Wieghofer P, Hagemeyer N, Sankowski R, Schlecht A, Staszewski O, Amann L, Gruber M, Koch J, Hausmann A, Zhang P, Boneva S, Masuda T, Hilgendorf I, Goldmann T, Böttcher C, Priller J, Rossi FMV, Lange C and Prinz M: Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling. EMBO J, e105123, doi: 10.15252/embj.2020105123 (2021).

Prinz M, Masuda T, Wheeler MA and Quintana FJ: Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation. Annu Rev Immunol 39, 251–77 (2021).

Regen T, Isaac S, Amorim A, Núñez NG, Hauptmann J, Shanmugavadivu A, Klein M, Sankowski R, Mufazalov IA, Yogev N, Huppert J, Wanke F, Witting M, Grill A, Gálvez EJC, Nikolaev A, Blanfeld M, Prinz I, Schmitt-Kopplin P, Strowig T, Reinhardt C, Prinz M, Bopp T, Becher B, Ubeda C, Waisman A: IL-17 controls central nervous system autoimmunity through the intestinal microbiome. Sci Immunol 6, eaaz6563 (2021).

Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S: Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cell. Cancers (Basel) 13(3):412; doi: 10.3390/cancers13030412 (2021).

Koelsche C, […], Prinz M, […], Von Deimlung A: Sarcoma classification by DNA methylation profiling. Nat Commun 12, 498 (2021).

Chhatbar C and Prinz M: The roles of microglia in viral encephalitis: from sensome to therapeutic targeting. Cellular & Molecular Immunology, 18, 250–258 (2021).

Schiele MA, Thiel C, Weidner M, Endres D, Zaudig M, Berberich G, Domschke K: Serotonin transporter gene promoter hypomethylation in obsessive-compulsive disorder – predictor of impaired response to exposure treatment? J Psychiatr Res 132, 18-22 (2021).

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