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Center for Basics in NeuroModulation
Center for Basics in NeuroModulation
Center for Basics in NeuroModulation
Center for Basics in NeuroModulation

Welcome to the Center for Basics in NeuroModulation

The Center for Basics in NeuroModulation (NeuroModulBasics) is an initiative of neuroscience researchers based in Freiburg to connect experts in neurosciences and, thus, strengthen the local research network. In the form of a “virtual center”, it supports neuroscience research to understand complex brain function from basic research to clinically relevant settings by joining interdisciplinary expertises and methods to create new ideas and concepts. NeuroModulBasics aims to decipher the mechanisms of how intrinsic and extrinsic factors modulate brain function and the risk for and resilience against CNS pertubations, in order to better understand how neuromodulatory treatments such as pharmacological and psychotherapeutic interventions or (non)-invasive brain stimulation confer their effects on molecular, cellular and system levels.

Research Program

Seminars

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Publications

Schwabenland M, Brück W, Priller J, Stadelmann C, Lassmann H and Prinz M: Analyzing microglial phenotypes across neuropathologies: a practical guide. Acta Neuropathologica; doi: 10.1007/s00401-021-02370-8 (2021).

Malik SC, Sozmen EG, Baeza-Raja B, Le Moan N, Akassoglou K, Schachtrup C: In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target. Trends in Pharmacological Science; S0165-6147(21)00134-6 (2021).

Chu Y-H, Lin J-d, Nath S, Schachtrup C: Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior. Cell and Tissue Research; doi: 10.1007/s00441-021-03490-z (2021).

Magalhaes J, Tresse E, Ejlerskov P, Hu E, Liu Y, Marin A, Montalant A, Satriano L, Friis Rundsten C, Meier Carlsen EM, Rydbirk R, Sharifi-Zarchi A, Bøje Andersen J, Aznar S, Brudek T, Khodosevich K, Prinz M, Perrier J-F M, Sharma M, Gasser T & Issazadeh-Navikas S: PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia. Molecular Psychiatry; DOI: 10.1038/s41380-021-01207-w (2021).

Galanis C, Fellenz M, Becker D, Bold C, Lichtenthaler SF, Müller UC, Deller T and Vlachos A: Amyloid-Beta Mediates Homeostatic Synaptic Plasticity. J Neurosci 41(24):5157-5172; doi: 10.1523/JNEUROSCI.1820-20.2021 (2021).

Baasch S, Giansanti P, Kolter J, Riedl A, Forde AJ, Runge S, Zenke S, Elling R, Halenius A, Brabletz S, Hengel H, Kuster B, Brabletz T, Cicin-Sain L, Arens R, Vlachos A, Rohr JC, Stemmler MP, Kopf M, Ruzsics Z, Henneke P: Cytomegalovirus subverts macrophage identity. Cell 184, 1-20 (2021).

Schwabenland M, Salié H, Tanevski J, Killmer S, Salvat Lago M, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch K-P, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B: Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions. Immunity; doi: https://doi.org/10.1016/j.immuni.2021.06.002 (2021).

Henneke P, Kierdorf K, Hall LJ, Sperandio M, Hornef M: Perinatal development of innate immune topology. Elife 10:e67793; doi: 10.7554/eLife.67793 (2021).

Friedrich M, Sankowski R, Bunse L, Kilian M, Green E, Ramallo Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Gegner HM, Sonner JK, von Landenberg A, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland DH, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana FJ, von Deimling A, Wick W, Prinz M & Platten M: Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Nature Cancer 2, 723–740 (2021).

Friedrich S-K, Schmitz R, Bergerhausen M, Lang J, Duhan V, Hardt C, Tenbusch M, Prinz M, Asano K, Bhat H, Hamdan TA, Lang PA, and Lang KS: Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation. Pathogens 10(5), 622; doi.org/10.3390/pathogens10050622 (2021).

Franco P, Huebschle I, Simon-Gabriel CP, Dacca K, Schnell O, Beck J, Mast H, Urbach H, Wuertemberger U, Prinz M, Hosp JA, Delev D, Mader I, Heiland DH: Mapping of Metabolic Heterogeneity of Glioma Using MR-Spectroscopy. Cancers (Basel) 13(10):2417; doi: 10.3390/cancers13102417 (2021).

Hsiao C-C, Sankowski R, Prinz M, Smolders J, Huitinga I, Hamann J: GPCRomics of Homeostatic and Disease-Associated Human Microglia. Front Immunol 12:674189; doi: 10.3389/fimmu.2021.674189 (2021).

Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao C-C, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ: Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science 372(6540):eabf1230; doi: 10.1126/science.abf1230 (2021).

Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A: Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity 54(4):648-659.e8; doi: 10.1016/j.immuni.2021.02.004 (2021).

Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT: Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19. Brain awab009; doi: 10.1093/brain/awab009 (2021).

Lenz M, Kruse P, Eichler A, Straehle J, Beck J, Deller T, Vlachos A: All-trans retinoic acid induces synaptic plasticity in human cortical neurons. Elife 10:e63026; doi: 10.7554/eLife.63026 (2021).

Turi Z, Lenz M, Paulus W, Mittner M, Vlachos A: Selecting stimulation intensity in repetitive transcranial magnetic stimulation studies: A systematic review between 1991 and 2020. Eur J Neurosci; doi: 10.1111/ejn.15195 (2021).

Emig RWiebke Knodt W, Krussig MJ, Zgierski-Johnston  CM, Gorka O, Groß O, Kohl P, Ravens U, Peyronnet R: Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing. Cells 10(3):663; doi: 10.3390/cells10030663 (2021).

Turi Z, Normann C, Domschke K, Vlachos A: Transcranial Magnetic Stimulation in Psychiatry: Is There a Need for Electric Field Standardization? Front Hum Neurosci 15:639640; doi: 10.3389/fnhum.2021.639640, eCollection (2021).

Lenz M, Eichler A, Vlachos A: Monitoring and Modulating Inflammation-Associated Alterations in Synaptic Plasticity: Role of Brain Stimulation and the Blood-Brain Interface.Biomolecules 11(3):359; doi: 10.3390/biom11030359 (2021).

Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C and Simons M: Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nature Metabolism 3, 211–227 (2021).

Hildebrandt-Einfeldt L, Yap K, Paul MH, Stoffer C, Zahn N, Alexander Drakew A, Lenz M, Vlachos A, Deller T: Crossed Entorhino-Dentate Projections Form and Terminate With Correct Layer-Specificity in Organotypic Slice Cultures of the Mouse Hippocampus. Front Neuroanat 15:637036; doi: 10.3389/fnana.2021.637036. eCollection (2021).

Kandadai KS, Kotur MB, Dokalis N, Amrein I, Keller CW, Münz C, Wolfer D, Prinz M and Lünemann JD: ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice. Autophagy 1-11; https://doi.org/10.1080/15548627.2021.1883880 (2021).

Wieghofer P, Hagemeyer N, Sankowski R, Schlecht A, Staszewski O, Amann L, Gruber M, Koch J, Hausmann A, Zhang P, Boneva S, Masuda T, Hilgendorf I, Goldmann T, Böttcher C, Priller J, Rossi FMV, Lange C and Prinz M: Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling. EMBO J, e105123, doi: 10.15252/embj.2020105123 (2021).

Prinz M, Masuda T, Wheeler MA and Quintana FJ: Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation. Annu Rev Immunol 39, 251–77 (2021).

Regen T, Isaac S, Amorim A, Núñez NG, Hauptmann J, Shanmugavadivu A, Klein M, Sankowski R, Mufazalov IA, Yogev N, Huppert J, Wanke F, Witting M, Grill A, Gálvez EJC, Nikolaev A, Blanfeld M, Prinz I, Schmitt-Kopplin P, Strowig T, Reinhardt C, Prinz M, Bopp T, Becher B, Ubeda C, Waisman A: IL-17 controls central nervous system autoimmunity through the intestinal microbiome. Sci Immunol 6, eaaz6563 (2021).

Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S: Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cell. Cancers (Basel) 13(3):412; doi: 10.3390/cancers13030412 (2021).

Koelsche C, […], Prinz M, […], Von Deimlung A: Sarcoma classification by DNA methylation profiling. Nat Commun 12, 498 (2021).

Chhatbar C and Prinz M: The roles of microglia in viral encephalitis: from sensome to therapeutic targeting. Cellular & Molecular Immunology 18, 250–258 (2021).

Schiele MA, Thiel C, Weidner M, Endres D, Zaudig M, Berberich G, Domschke K: Serotonin transporter gene promoter hypomethylation in obsessive-compulsive disorder – predictor of impaired response to exposure treatment? J Psychiatr Res 132, 18-22 (2021).

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