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Center for Basics in NeuroModulation
Center for Basics in NeuroModulation
Center for Basics in NeuroModulation
Center for Basics in NeuroModulation

Welcome to the Center for Basics in NeuroModulation

The Center for Basics in NeuroModulation (NeuroModulBasics) is an initiative of neuroscience researchers based in Freiburg to connect experts in neurosciences and, thus, strengthen the local research network. In the form of a “virtual center”, it supports neuroscience research to understand complex brain function from basic research to clinically relevant settings by joining interdisciplinary expertises and methods to create new ideas and concepts. NeuroModulBasics aims to decipher the mechanisms of how intrinsic and extrinsic factors modulate brain function and the risk for and resilience against CNS pertubations, in order to better understand how neuromodulatory treatments such as pharmacological and psychotherapeutic interventions or (non)-invasive brain stimulation confer their effects on molecular, cellular and system levels.

Research Program

Publications

Ravi VM, Will P, Kueckelhaus J, Sun N, Joseph K, Salié H, . . . Prinz M, . . .Heiland DH: Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma. Cancer Cell, 40(6), 639-655.e613 (2022).

Friedrich M, Hahn M, Michel J, Sankowski R, Kilian M, Kehl N, . . . Prinz M, . . . Bunse L: Dysfunctional dendritic cells limit antigen-specific T cell response in glioma. Neuro-Oncology. https://doi.org/10.1093/neuonc/noac138 (2022).

Kolter J, Henneke P, Groß O, Kierdorf K, Prinz M, Graf L & Schwemmle M: Paradoxical immunodeficiencies – When failures of innate immunity cause immunopathology. European Journal of Immunology https://doi.org/10.1002/eji.202149531 (2022).

Boettler T, Csernalabics B, Salié H, Luxenburger H, Wischer L, Salimi Alizei E, Zoldan K, Krimmel L, Bronsert P, Schwabenland M, Prinz M, Mogler C, Neumann-Haefelin C, Thimme R, Hofmann M, and Bengsch B: SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis. J Hepatol; doi: 10.1016/j.jhep.2022.03.040 (2022).

Steinkellner H, Kempaiah P, Beribisky AV, Pferschy S, Etzler J, Huber A, Sarne V, Neuhaus W, Kuttke M, Bauer J, Arunachalam JP, Christodoulou J, Dressel R, Mildner A, Prinz M, Laccone F: TAT-MeCP2 protein variants rescue disease phenotypes in human and mouse models of Rett syndrome. Int J Biol Macromol 209(Pt A):972-983; doi: 10.1016/j.ijbiomac.2022.04.080 2022).

Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M: Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature 604(7907):740-748; doi: 10.1038/s41586-022-04596-2 (2022).

Matsudaira T & Prinz M: Life and death of microglia: Mechanisms governing microglial states and fates. Immunol Lett 245:51-60; doi: 10.1016/j.imlet.2022.04.001 (2022).

Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford AL, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy KJ, Gagliani N, Flavell RA, Waisman A, Huber S: CD4 + T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival. Cell Rep 38(13):110565; doi: 10.1016/j.celrep.2022.110565 (2022).

Erny D, Dokalis N, Mezö C, Mossad O, Blank T, Prinz M: Flow-cytometry-based protocol to analyze respiratory chain function in mouse microglia. STAR Protoc 3(1):101186; doi: 10.1016/j.xpro.2022.101186 (2022).

Conforti P, Mezey S, Nath S, Chu Y-H, Malik SC, Martínez Santamaría JC, Deshpande SS, Pous L, Zieger B, Schachtrup C: Fibrinogen regulates lesion border-forming reactive astrocyte properties after vascular damage. Glia, doi: 10.1002/glia.24166 (2022).

Schachtrup C: Modulating scar formation for improving brain repair: from coagulation and inflammation to cell therapy. Cell Tissue Res, doi: 10.1007/s00441-022-03601-4 (2022).

Dudek M, Lohr K, Donakonda S, Baumann T, Lüdemann M, Hegenbarth S, Dübbel L, Eberhagen C, Michailidou S, Yassin A, Prinz M, Popper B, Rose-John S, Zischka H, Knolle PA: IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells. Cell Rep 38(7):110389; doi: 10.1016/j.celrep.2022.110389 (2022).

Czeh M, Stäble S, Krämer S, Tepe L, Talyan S, Carrelha J, Meng Y, Heitplatz B, Schwabenland M, Milsom MD, Plass C, Prinz M, Schlesner M, Andrade-Navarro MA, Nerlov C, Jacobsen SEW, Lipka DB, Rosenbauer F: DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease. J Immunol 208(2), 358-370 (2022).

Kleis P, Paschen E, Häussler U, Bernal Sierra YA, Haas CA: Long-term in vivo characterization and application of a novel potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus. BMC Biology 20, 18 (2022).

Ebrahimi A, Korshunov A, Reifenberger G, Capper D, Felsberg J, Trisolini E, Pollo B, Calatozzolo C, Prinz M, Staszewski O, Schweizer L, Schittenhelm J, Harter PN, Paulus W, Thomas C, Kohlhof‑Meinecke P, Seiz‑Rosenhagen M, Milde T, Casalini BM, Suwala A, Wefers AK, Reinhardt A, Sievers P, Kramm CM, Etminam N, Unterberg A, Wick W, Herold‑Mende C, Sturm D, Pfister SM, Sill M, Jones DTW, Schrimpf D, Reuss DE, Aldape K, Abdullaev Z, Sahm F, von Deimling A and Stichel D: Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival. Acta Neuropathol Commun 10(1):5 (2022).

Neidert N, Strähle J, Erny D, Sacalean V, El Rahal A, Steybe D, Schmelzeisen R, Vlachos A, Reinacher PC, Coenen VA, Mizaikoff B, Heiland DH, Prinz M, Beck J, Schnell O: Stimulated Raman histology in the neurosurgical workflow of a major European neurosurgical center – part A. Neurosurg Rev; doi: 10.1007/s10143-021-01712-0 (2021).

Chhatbar, C, Prinz M: From shape to contents: heterogeneity of CNS glial cells. Acta Neuropathol 143(2), 123-124 (2022).

d’Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Sebastian Monasor L, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M: Microglia contribute to the propagation of Aβ into unaffected brain tissue. Nat Neurosci; doi: 10.1038/s41593-021-00951-0 (2021).

Kettwig M, Ternka K, Prinz M, Nessler S, Gärtner J: Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nature Communications 12, 6530 (2021).

Vestring S, Domschke K, Normann K: Ketamin und andere N-Methyl-DAspartat- Rezeptor-Modulatoren zur Behandlung der Depression. Der Nervenarzt; doi 10.1007/s00115-021-01221-x (2021).

Cauwels A, van Lint S, Rogge E, Verhee A, van den Eeckhout B, Pang S, Prinz M, Kley N, Uzé G, Tavernier J: Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE. Scientific Reports 11, 21575 (2021).

Erny D, Dokalis N, Mezö C, Castoldi A, Mossad O, Staszewski O, Frosch M, Villa M, Fuchs V, Mayer A, Neuber J, Sosat J, Tholen S, Schilling O, Vlachos A, Blank T, Gomez de Agüero M, Macpherson AJ, Pearce EJ, Prinz M: Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease. Cell Metab 33(11); 2260-2276.e7 (2021).

Schneider M, Vollmer L, Potthoff A-L, Ravi VM, Evert BO, Rahman MA, Sarowar S, Kueckelhaus J, Will P, Zurhorst D, Joseph K, Maier JP, Neidert N, d’Errico P, Meyer-Luehmann M, Hofmann UG, Dolf A, Salomoni P, Güresir E, Enger PØ, Chekenya M, Pietsch T, Schuss P, Schnell O, Westhoff MA, Beck J, Vatter H, Waha A, Herrlinger U, Heiland DH: Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma. Neuro Oncol;23(11):1885-1897. doi: 10.1093/neuonc/noab092 (2021).

Friesen M, Ziegler-Waldkirch S, Egenolf M, d’Errico P, Helm C, Mezö C, Dokalis N, Erny D, Katzmarski N, Coelho R, Loreth D, Prinz M, Meyer-Luehmann M: Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α-syn co-pathology. Brain Pathol;e13032.doi: 10.1111/bpa.13032 (2021).

Friedel EBN, Tebartz van Elst L, Schmelz C, Ebert D, Maier S, Endres D, Runge K, Domschke K, Bubl E, Kornmeier J, Bach M, Heinrich SP, Nickel K: Replication of Reduced Pattern Electroretinogram Amplitudes in Depression With Improved Recording Parameters. Front Med (Lausanne) 8:732222 (2021).

Manchia M, Gathier AW, Yapici-Eser H, Schmidt MV, de Quervain D, van Amelsvoort T, Bisson JI, Cryan JF, Howes OD, Pinto L, van der Wee NJ, Domschke K, Branchi I, Vinkers CH: The impact of the prolonged COVID-19 pandemic on stress resilience and mental health: A critical review across waves. Eur Neuropsychopharmacol 55, 22-83 (2021).

Schroeder A, Letzkus JJ: A neuropeptide making memories. Cell 184(22):5501-5503 (2021).

Braune M, Scherf N, Heine C, Sygnecka K, Pillaiyar T, Parravicini C, Heimrich B, Abbracchio MP, Müller CE, Franke H: Involvement of GPR17 in Neuronal Fibre Outgrowth. Int J Mol Sci 22, 11683 (2021)

Deshpande SS, Malik SC, Conforti P, Lin J, Chu Y-H, Nath S, Greulich F, Dumbach M-A, Uhlenhaut NH, Schachtrup C: P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke. Cell and Tissue Research, doi: 10.1007/s00441-021-03539-z (2021).

Borst K, Dumas AA, Prinz M: Microglia: Immune and non-immune functions. Immunity 54(10), 2194-2208 (2021).

Feige B, Baglioni C, Boehm P, Heinrich A, Trumm S, Benz F, Nissen C, Domschke K, Frase L, Riemann D: Event-related potentials in insomnia reflect altered perception of sleep. Sleep 44(10); zsab137 (2021).

Heinisch O, Zeyen T, Goldmann T, Prinz M, Huber M, Jung J, Arik E, Habib S, Slowik A, Reich A, Schulz JB, Habib P: Erythropoietin Abrogates Post-Ischemic Activation of the NLRP3, NLRC4, and AIM2 Inflammasomes in Microglia/Macrophages in a TAK1-Dependent Manner. Transl Stroke Res; doi: 10.1007/s12975-021-00948-8 (2021).

Schwabenland M, Brück W, Priller J, Stadelmann C, Lassmann H and Prinz M: Analyzing microglial phenotypes across neuropathologies: a practical guide. Acta Neuropathologica; doi: 10.1007/s00401-021-02370-8 (2021).

Lu H, Gallinaro JV, Normann C, Rotter S, Yalcin I: Time Course of Homeostatic Structural Plasticity in Response to Optogenetic Stimulation in Mouse Anterior Cingulate. CortexCereb Cortex; doi: 10.1093/cercor/bhab281 (2021).

Maihofer AX, […], Domschke K, […], Nievergelt CM: Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biol Psychiatry S0006-3223(21)01632-2 (2021).

Vestring S, Serchov T, Normann C: Animal Models of Depression – Chronic Despair Model (CDM). J Vis Exp; doi: 10.3791/62579 (2021).

Zhang P, Schlecht A, Wolf J, Boneva S, Laich Y, Koch J, Ludwig F, Boeck M, Thien A, Härdtner C, Kierdorf K, Agostini H, Schlunck G, Prinz M, Hilgendorf I, Wieghofer P & Lange C: The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation. Journal of Neuroinflammation 18, 215 (2021).

Hein G, Gamer M, Gall D, Gründahl M, Domschke K, Andreatta M, Wieser MJ, Pauli P: Social cognitive factors outweigh negative emotionality in predicting COVID-19 related safety behaviors. Prev Med Rep 24, 101559 (2021).

Dumas AA, Borst K, Prinz M: Current tools to interrogate microglial biology. Neuron 109(18):2805-2819 (2021).

Schiele MA, Vietz M, Gajewska A, Unterecker S, Gottschalk MG, Deckert J, Neufang S, Schmidt NB, Domschke K: The cognitive anxiety sensitivity treatment (CAST) in anxiety prevention – Focus on separation anxiety and interoception. European Neuropsychopharmacology 53, 104-113 (2021).

Demerath T, Donkels C, Reisert M, Heers M, Rau A, Schröter N, Schulze-Bonhage A, Reinacher P, Scheiwe C, Shah MJ, Beck J, Vlachos A, Haas CA, Urbach H: Gray-white matter blurring of the temporal pole associated with hippocampal sclerosis: A microstructural study involving 3T MRI and ultrastructural histopathology. Cerebral Cortex, doi:10.1093/cercor/bhab320 (2021).

Arango C, Dragioti E, Solmi M, Cortese S, Domschke K, Murray RM, Jones PB, Uher R, Carvalho AF, Reichenberg A, Shin JII, Andreassen OA, Correll CU, Fusar-Poli P: Risk and protective factors for mental disorders beyond genetics: an evidence-based atlas. World Psychiatry 20(3):417-436 (2021).

von Zedtwitz K, Matteit I, Michel M, Feige B, Runge K, Denzel D, Schlump A, Nickel K, Schiele MA, Berger B, Prüss H, Urbach H, Domschke K, Tebartz van Elst L, Endres D: Anti-MOG autoantibody-associated schizophreniform psychosis. Acta Neuropsychiatr 1-8 (2021).

Kleis P, Paschen E, Häussler U, Bernal Sierra YA, Haas CA: Long-term in vivo characterization and application of a novel potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus. BMC Biology, (in press).

Meyer PT, Blazhenets G, Prinz M, Hosp JA: Reply: From early limbic inflammation to long COVID sequelae. Brain 144(8):e66 (2021).

Villanueva EB, Tresse E, Liu Y, Duarte JN, Jimenez-Duran G, Ejlerskov P, Kretz O, Loreth D, Goldmann T, Prinz M, Issazadeh-Navikas S: Neuronal TNFα, Not α-Syn, Underlies PDD-Like Disease Progression in IFNβ-KO Mice. Ann Neurol 90(5):789-807 (2021).

Hinze J, Röder A, Menzie N, Müller U, Domschke K, Riemenschneider M, Noll-Hussong M: Spider Phobia: Neural Networks Informing Diagnosis and (Virtual/Augmented Reality-Based) Cognitive Behavioral Psychotherapy—A Narrative Review. Front Psychiatry 12, 704174 (2021).

Orcinha C, Kilias A, Paschen E, Follo M and Haas CA: Reelin is required for maintenance of granule cell lamination in the healthy and epileptic hippocampus. Front Mol Neurosci 14:730811 (2021).

Kumpf U, Stadler M, Plewnia C, Bajbouj M, Langguth B, Zwanzger P, Normann C, Keeser D, Schellhorn K, Egert-Schwender S, Berkes S, Palm U, Hasan A, Padberg F: Transcranial Direct Current Stimulation (tDCS) for major depression – Interim analysis of cloud supervised technical data from the DepressionDC tria. Brain Stimul 14(5), 1234-1237 (2021).

Salazar de Pablo G, Solmi M, Vaquerizo-Serrano J, Radua J, Passina A, Mosillo P, Correll CU, Borgwardt S, Galderisi S, Bechdolf A, Pfennig A, Bauer M, Vedel Kessing L, van Amelsvoort T, Nieman DH, Domschke K, Krebs M-O, Sand M, Vieta E, McGuire P, Arango C, Shin JI, Fusar-Poli P: Primary prevention of depression: An umbrella review of controlled interventions. J Affect Disord 294, 957-970 (2021).

Feng Y, Dionne MS, Stamatiades EG and Kierdorf K: Editorial: Deciphering Phagocyte Functions Across Different Species. Front Cell Dev Biol; 9, 712929 (2021).

Malik SC, Sozmen EG, Baeza-Raja B, Le Moan N, Akassoglou K, Schachtrup C: In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target. Trends in Pharmacological Science; S0165-6147(21)00134-6 (2021).

Manzouri F, Meisel C, Kunz L, Dümpelmann M, Stieglitz T, Schulze-Bonhage A: Low-frequency electrical stimulation reduces cortical excitability in the human brain. Neuroimage Clin 31, 102778 (2021).

Chu Y-H, Lin J-d, Nath S, Schachtrup C: Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior. Cell and Tissue Research; doi: 10.1007/s00441-021-03490-z (2021).

Pittig A, Heinig I, Goerigk S, Thiel F, Hummel K, Scholl L, Deckert J, Pauli P, Domschke K, Lueken U, Fydrich T, Fehm L, Plag J, Ströhle A, Kircher T, Straube B, Rief W, Koelkebeck K, Arolt V, Dannlowski U, Margraf J, Totzeck C, Schneider S, Neudeck P, Craske MG, Hollandt M, Richter J, Hamm A, Wittchen H-U: Efficacy of temporally intensified exposure for anxiety disorders: A multicenter randomized clinical trial. Depress Anxiety 38(11), 1169-1181 (2021).

Merz J, Nettesheim A, von Garlen S, Albrecht P, Saller BS, Engelmann J, Hertle L, Schäfer I, Dimanski D, König S, Karnbrock L, Bulatova K, Peikert A, Hoppe N, Hilgendorf I, von Zur Mühlen C, Wolf D, Groß O, Bode C, Zirlik A, Stachon P: Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile. Purinergic Signal 17(3), 481-492 (2021).

Magalhaes J, Tresse E, Ejlerskov P, Hu E, Liu Y, Marin A, Montalant A, Satriano L, Friis Rundsten C, Meier Carlsen EM, Rydbirk R, Sharifi-Zarchi A, Bøje Andersen J, Aznar S, Brudek T, Khodosevich K, Prinz M, Perrier J-F M, Sharma M, Gasser T & Issazadeh-Navikas S: PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia. Molecular Psychiatry; DOI: 10.1038/s41380-021-01207-w (2021).

Villarreal A, Vogel T: Different Flavors of Astrocytes: Revising the Origins of Astrocyte Diversity and Epigenetic Signatures to Understand Heterogeneity after Injury. Int J Mol Sci 22(13):6867 (2021).

Meixensberger S, Kuzior H, Fiebich BL, Süß P, Runge K, Berger B, Nickel K, Denzel D, Schiele MA, Michel M, Maier S, Bechter K, Domschke K, Tebartz van Elst L and Endres D: Upregulation of sICAM-1 and sVCAM-1 Levels in the Cerebrospinal Fluid of Patients with Schizophrenia Spectrum Disorders. Diagnostics 11(7), 1134 (2021).

Galanis C, Fellenz M, Becker D, Bold C, Lichtenthaler SF, Müller UC, Deller T and Vlachos A: Amyloid-Beta Mediates Homeostatic Synaptic Plasticity. J Neurosci 41(24):5157-5172; doi: 10.1523/JNEUROSCI.1820-20.2021 (2021).

Endres D, Runge K, Meixensberger S, Feige B, Denzel D, Pankratz B, Maier S, Nickel K, Michel M, Venhoff N, Schiele MA, Domschke K, Prüss H, Tebartz van Elst L: An observational study on the association of anti-thyroid autoantibodies with clinical, EEG, MRI, FDG-PET, cerebrospinal fluid and anti-neuronal antibody findings in 530 patients with schizophreniform and affective disorder. Psychoneuroendocrinology 131; 105320 (2021).

Baasch S, Giansanti P, Kolter J, Riedl A, Forde AJ, Runge S, Zenke S, Elling R, Halenius A, Brabletz S, Hengel H, Kuster B, Brabletz T, Cicin-Sain L, Arens R, Vlachos A, Rohr JC, Stemmler MP, Kopf M, Ruzsics Z, Henneke P: Cytomegalovirus subverts macrophage identity. Cell 184, 1-20 (2021).

Schwabenland M, Salié H, Tanevski J, Killmer S, Salvat Lago M, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch K-P, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B: Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions. Immunity; doi: https://doi.org/10.1016/j.immuni.2021.06.002 (2021).

Henneke P, Kierdorf K, Hall LJ, Sperandio M, Hornef M: Perinatal development of innate immune topology. Elife 10:e67793; doi: 10.7554/eLife.67793 (2021).

Friedrich M, Sankowski R, Bunse L, Kilian M, Green E, Ramallo Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Gegner HM, Sonner JK, von Landenberg A, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland DH, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana FJ, von Deimling A, Wick W, Prinz M & Platten M: Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Nature Cancer 2, 723–740 (2021).

Michel M, Fiebich BL, Kuzior H, Meixensberger S, Berger B, Maier S, Nickel K, Runge K, Denzel D, Pankratz B, Schiele MA, Domschke K, Tebartz van Elst L & Endres D: Increased GFAP concentrations in the cerebrospinal fluid of patients with unipolar depression. Translational Psychiatry 11, 308 (2021).

Friedrich S-K, Schmitz R, Bergerhausen M, Lang J, Duhan V, Hardt C, Tenbusch M, Prinz M, Asano K, Bhat H, Hamdan TA, Lang PA, and Lang KS: Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation. Pathogens 10(5), 622; doi.org/10.3390/pathogens10050622 (2021).

Domschke K: Prevention in psychiatry: a role for epigenetics? World Psychiatry 20(2); 227-228.

Franco P, Huebschle I, Simon-Gabriel CP, Dacca K, Schnell O, Beck J, Mast H, Urbach H, Wuertemberger U, Prinz M, Hosp JA, Delev D, Mader I, Heiland DH: Mapping of Metabolic Heterogeneity of Glioma Using MR-Spectroscopy. Cancers (Basel) 13(10):2417; doi: 10.3390/cancers13102417 (2021).

Hsiao C-C, Sankowski R, Prinz M, Smolders J, Huitinga I, Hamann J: GPCRomics of Homeostatic and Disease-Associated Human Microglia. Front Immunol 12:674189; doi: 10.3389/fimmu.2021.674189 (2021).

Domschke K: Update Angsterkrankungen – aktueller Stand und neue Entwicklungen. Der Nervenarzt 92(5); 415–416 (2021).

Treppner M, Salas-Bastos A, Hess M, Lenz S, Vogel T, Binder H: Synthetic single cell RNA sequencing data from small pilot studies using deep generative models. Sci Rep;11(1):9403 (2021).

Hatscher L, Lehmann Christian HK, Purbojo A, Onderka C, Liang C, Hartmann A, Cesnjevar R, Bruns H, Groß O, Nimmerjahn F, Ivanović-Burmazović I, Kunz M, Heger LA, Dudziak D: Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells. Sci Signal 14(680):eabe1757 (2021).

Prinz M, Masuda T, Wheeler M, Quintana FJ: Microglia and Central Nervous System – Associated Macrophages-From Origin to Disease Modulation. Annu Rev Immunol 39, 251-277 (2021).

Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao C-C, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ: Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science 372(6540):eabf1230; doi: 10.1126/science.abf1230 (2021).

Runge K, Fiebich BL, Kuzior H, Saliba SW, Yousif NM, Meixensberger S, Nickel K, Denzel D, Schiele MA, Maier SJ, Berger B, Dersch R, Domschke K, Tebartz van Elst L, Endres D: An observational study investigating cytokine levels in the cerebrospinal fluid of patients with schizophrenia spectrum disorders. Schizophr Res 231, 205-213 (2021).

Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A: Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity 54(4):648-659.e8; doi: 10.1016/j.immuni.2021.02.004 (2021).

Domschke K: Targeted prevention of anxiety disorders. Eur Neuropsychopharmacol 46; 49-51 (2021).

Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT: Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19. Brain awab009; doi: 10.1093/brain/awab009 (2021).

Lenz M, Kruse P, Eichler A, Straehle J, Beck J, Deller T, Vlachos A: All-trans retinoic acid induces synaptic plasticity in human cortical neurons. Elife 10:e63026; doi: 10.7554/eLife.63026 (2021).

Turi Z, Lenz M, Paulus W, Mittner M, Vlachos A: Selecting stimulation intensity in repetitive transcranial magnetic stimulation studies: A systematic review between 1991 and 2020. Eur J Neurosci; doi: 10.1111/ejn.15195 (2021).

Pini S, Abelli M, Costa B, Martini C, Schiele MA, Baldwin DS, Bandelow B, Domschke K: Separation Anxiety and Measures of Suicide Risk Among Patients With Mood and Anxiety Disorders. J Clin Psychiatry 82(2):20m13299 (2021).

Emig RWiebke Knodt W, Krussig MJ, Zgierski-Johnston  CM, Gorka O, Groß O, Kohl P, Ravens U, Peyronnet R: Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing. Cells 10(3):663; doi: 10.3390/cells10030663 (2021).

Freiman TM, Häussler U, Zentner J, Dooskamp S, Beck J, Scheiwe C; Brandt A, Haas CA, Puhahn-Schmeiser B: Hippocampal mossy fiber sprouting into CA2 in temporal lobe epilepsy. Hippocampus 31:580-592 (2021).

Endres D, Werden R, Schweizer T, Schröter N, Schiele MA, Nickel K, Fischer M, Domschke K, Urbach H, Meyer PT, Prüss H, Tebartz van Elst L: Novel Neuronal Autoantibodies in Huntington’s Disease. Biol Psychiatry S0006-3223(21)00043-3 (2021).

Turi Z, Normann C, Domschke K, Vlachos A: Transcranial Magnetic Stimulation in Psychiatry: Is There a Need for Electric Field Standardization? Front Hum Neurosci 15:639640; doi: 10.3389/fnhum.2021.639640, eCollection (2021).

Lenz M, Eichler A, Vlachos A: Monitoring and Modulating Inflammation-Associated Alterations in Synaptic Plasticity: Role of Brain Stimulation and the Blood-Brain Interface.Biomolecules 11(3):359; doi: 10.3390/biom11030359 (2021).

Barghoorn A, Riemenschneider B, Hennig J, LeVan P: Improving the sensitivity of spin-echo fMRI at 3T by highly accelerated acquisitions. Magn Reson Med 86, 245–257 (2021).

Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, CA Brunello, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E: Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184, 1299–1313,(2021).

Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C and Simons M: Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nature Metabolism 3, 211–227 (2021).

Hildebrandt-Einfeldt L, Yap K, Paul MH, Stoffer C, Zahn N, Alexander Drakew A, Lenz M, Vlachos A, Deller T: Crossed Entorhino-Dentate Projections Form and Terminate With Correct Layer-Specificity in Organotypic Slice Cultures of the Mouse Hippocampus. Front Neuroanat 15:637036; doi: 10.3389/fnana.2021.637036. eCollection (2021).

Kandadai KS, Kotur MB, Dokalis N, Amrein I, Keller CW, Münz C, Wolfer D, Prinz M and Lünemann JD: ATG5 in microglia does not contribute vitally to autoimmune neuroinflammation in mice. Autophagy 1-11; https://doi.org/10.1080/15548627.2021.1883880 (2021).

Prinz M, Masuda T, Wheeler MA and Quintana FJ: Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation. Annu Rev Immunol 39, 251–77 (2021).

Wieghofer P, Hagemeyer N, Sankowski R, Schlecht A, Staszewski O, Amann L, Gruber M, Koch J, Hausmann A, Zhang P, Boneva S, Masuda T, Hilgendorf I, Goldmann T, Böttcher C, Priller J, Rossi FMV, Lange C and Prinz M: Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling. EMBO J, e105123, doi: 10.15252/embj.2020105123 (2021).

Regen T, Isaac S, Amorim A, Núñez NG, Hauptmann J, Shanmugavadivu A, Klein M, Sankowski R, Mufazalov IA, Yogev N, Huppert J, Wanke F, Witting M, Grill A, Gálvez EJC, Nikolaev A, Blanfeld M, Prinz I, Schmitt-Kopplin P, Strowig T, Reinhardt C, Prinz M, Bopp T, Becher B, Ubeda C, Waisman A: IL-17 controls central nervous system autoimmunity through the intestinal microbiome. Sci Immunol 6, eaaz6563 (2021).

Bauer C, Quante M, Breunis WB, Regina C, Schneider M, Andrieux G, Gorka O, Groß O, Boerries M, Kammerer B, Hettmer S: Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cell. Cancers (Basel) 13(3):412; doi: 10.3390/cancers13030412 (2021).

Wurst C, Schiele MA, Stonawski S, Weiß C, Nitschke F, Hommers L, Domschke K, Herrmann MJ, Pauli P, Deckert J, Menke A: Impaired fear learning and extinction, but not generalization, in anxious and non-anxious depression. J Psychiatr Res 135:294-301 (2021).

Koelsche C, […], Prinz M, […], Von Deimlung A: Sarcoma classification by DNA methylation profiling. Nat Commun 12, 498 (2021).

Schiele MA, Reif A, Lin J, Alpers GW, Andersson E, Andersson G, Arolt V, Bergström J, Carlbring P, Eley TC, Esquivel G, Furmark T, Gerlach AL, Hamm A, Helbig-Lang S, Hudson JL, Lang TL, Lester KJ, Lindefors N, Lonsdorf TB, Pauli P, Richter J, Rief W, Roberts S, Rück C, Schruers KRJ, Thiel C, Wittchen H-U, Domschke K, Weber H, Lueken U: Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis. European Neuropsychopharmacology 44, 105-120 (2021).

Chhatbar C and Prinz M: The roles of microglia in viral encephalitis: from sensome to therapeutic targeting. Cellular & Molecular Immunology 18, 250–258 (2021).

Menke A, Nitschke F, Hellmuth A, Helmel J, Wurst C, Stonawski S, Blickle M, Weiß C, Weber H, Hommers L, Domschke K, Deckert J: Stress impairs response to antidepressants via HPA axis and immune system activation. Brain Behav Immun 93:132-140 (2021).

Domschke K, Schiele MA, Romanos M: Prävention von Angsterkrankungen. Der Nervenarzt 92, 450–456 (2021).

Frase L, Mertens L, Krahl A, Bhatia K, Feige B, Heinrich SP, Vestring S, Nissen C, Domschke K, Bach M & Normann C: Transcranial direct current stimulation induces long-term potentiation-like plasticity in the human visual cortex. Translational Psychiatry 11, 17 (2021).

Siminski N, Bohme S, Zeller JBM, Becker MPI, Bruchmann M, Hofmann D, Breuer F, Muhlberger A, Schiele MA, Weber H, Schartner C, Deckert J, Pauli P, Reif A, Domschke K, Straube T, Herrmann MJ: BNST and amygdala activation to threat: Effects of temporal predictability and threat mode. Behav Brain Res 396:112883 (2021).

Schiele MA, Thiel C, Weidner M, Endres D, Zaudig M, Berberich G, Domschke K: Serotonin transporter gene promoter hypomethylation in obsessive-compulsive disorder – predictor of impaired response to exposure treatment? J Psychiatr Res 132, 18-22 (2021).

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