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Center for Basics in NeuroModulation
Center for Basics in NeuroModulation
Center for Basics in NeuroModulation
Center for Basics in NeuroModulation

Welcome to the Center for Basics in NeuroModulation

The Center for Basics in NeuroModulation (NeuroModulBasics) is an initiative of neuroscience researchers based in Freiburg to connect experts in neurosciences and, thus, strengthen the local research network. In the form of a “virtual center”, it supports neuroscience research to understand complex brain function from basic research to clinically relevant settings by joining interdisciplinary expertises and methods to create new ideas and concepts. NeuroModulBasics aims to decipher the mechanisms of how intrinsic and extrinsic factors modulate brain function and the risk for and resilience against CNS pertubations, in order to better understand how neuromodulatory treatments such as pharmacological and psychotherapeutic interventions or (non)-invasive brain stimulation confer their effects on molecular, cellular and system levels.

Research Program

Publications

Schiele MA, Thiel C, Weidner M, Endres D, Zaudig M, Berberich G, Domschke K: Serotonin transporter gene promoter hypomethylation in obsessive-compulsive disorder – predictor of impaired response to exposure treatment? J Psychiatr Res 132, 18-22 (2021).

Paschen E, Elgueta C, Heining K, Vieira D, Kleis P, Orcinha C, Häussler U, Bartos M, Egert U, Janz P, Haas CA: Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy. eLife 9:e54518. doi: 10.7554/eLife.54518 (2020).

Lenz M, Eichler A, Kruse P, Strehl A, Rodriguez-Rozada S, Goren I, Yogev N, Frank S, Waisman A, Deller T, Jung S, Maggio N and Vlachos A: Interleukin 10 Restores Lipopolysaccharide-Induced Alterations in Synaptic Plasticity Probed by Repetitive Magnetic Stimulation. Front Immunol; doi: 10.3389/fimmu.2020.614509 (2020).

Schiele MA, Domschke K: Separation anxiety disorder. Der Nervenarzt; doi: 10.1007/s00115-020-01037-1 (2020).

Fibrinogen triggered signaling pathways modify stem cell behavior in central nervous system disease. Nural Regen Res 16 (6), 1196-1197; doi: 10.4103/1673-5374.300436 (2020).

Schneider R, Bellenberg B, Gisevius B, Hirschberg S, Sankowski R, Prinz M, Gold R, Lukas C, Haghikia A: Chitinase 3–like 1 and neurofilament light chain in CSF and CNS atrophy in MS. Neurol Neuroimmunol Neuroinflamm 8(1), e906 (2021).

Schiele MA, Zwanzger P, Schwarte K, Arolt V, Baune BT, Domschke K: Serotonin transporter gene promoter hypomethylation as a predictor of antidepressant treatment response in major depression – a replication study, Int J Neuropsychopharmacol, (2020).

Schiele M, Bandelow B, Baldwin D, Pini S, Domschke K: A neurobiological framework of separation anxiety and related phenotypes. Eur Neuropsychopharmacol 33, 45-57 (2020).

Erny D, Jakobsdóttir KB, Prinz M: Neuropathological evaluation of vertebrate brain aged ~ 245 years. Acta Neuropathol; doi: 10.1007/s00401-020-02237-4 (2020).

Borst K, and Prinz M: Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single cell era. Brain Pathol, e12910, doi: 10.1111/bpa.12910 (2020).

Ferrari F, Arrigoni L, Franz H, Izzo A, Butenko L, Trompouki E and Vogel T: DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility. Nat Commun 11, 5200 (2020).

Ollmann TM, Voss C, Venz J, Seidl E, Hoyer J, Kische H, Pieper L, Schiele MA, Domschke K*, Beesdo-Baum K*: The Interaction of 5-HTT variation, recent stress and resilience on current anxiety levels in adolescents and young adults from the general population. Depress Anxiety, doi: 10.1002/da.23101 (2020).

Matschke J, Lütgehetmann M, Hagel C, Sperhake  JP, Schröder AS, Edler C, Mushumba H, Fitzek  A, Allweiss  L,  Dandri M, Dottermusch  M, Heinemann A, Pfefferle S, Schwabenland M, Magruder  DS, Bonn S, Prinz M, Gerloff C, Püschel K, Krasemann S, Aepfelbacher M, Glatzel M:  Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol 19(11), 919-929 (2020).

Lacinova L, Mallmann RT, Jurkovičová-Tarabováa B, and Klugbauer N: Modulation of voltage-gated CaV2.2 Ca2+ channels by newly identified interaction partners. Channels; doi: 10.1080/19336950.2020.1831328 (2020).

Dumas A, and Prinz M: The myeloid side of the CNS. Brain Pathol; doir 10.1111/bpa.12907 (2020).

Oschwald A, Petry P, Kierdorf K and Erny D: CNS Macrophages and Infant Infections. Front. Immunol., doi: 10.3389/fimmu.2020.02123 (2020).

Schiele MA, Thiel C, Fürst L, Putschin L, Kehle R, Hauke W, Mahr M, Reinhold E, Gottschalk MG, Heinrichs M, Zaudig M, Berberich G, Domschke K: Oxytocin receptor DNA methylation – a biomarker of treatment response in obsessive-compulsive disorder? Psychother Psychosom, doi: 10.1159/000509910 (2020).

Endres D, Maier V, Leypoldt F, Wandinger K-P, Lennox B, Pollak TA, Nickel K, Maier S, Feige B, Domschke K, Prüss H, Bechter K, Dersch R and Tebartz van Elst L: Autoantibody-associated psychiatric syndromes: a systematic literature review resulting in 145 cases. Psychol Med, 1-12; doi: 10.1017/S0033291720002895 (2020).

Bassett DS, Cullen KE, Eickhoff SB, Farah MJ, Goda Y, Haggard P, Hu H, Hurd YL, Josselyn SA, Khakh BS, Knoblich JA, Poirazi P, Poldrack RA, Prinz M, Roelfsema PR, Spires-Jones TL, Sur M, Ueda HR: Reflections on the past two decades of neuroscience. Nat Rev Neuroci 21(10), 524-534 (2020).

Schramm E, Klein DN, Elsässer M, Furukawa TA, Domschke K: Review of dysthymia and persistent depressive disorder: History, correlates, and clinical implications. Lancet Psychiatry 7, 801-812 (2020).

Montesinos-Rongen M, Brunn A, Tuchscherer  A, Borchmann  P, Schorb  E, Kasenda  B, Altmüller  J, Illerhaus G, Ruge MI, Maarouf  M, Büttner R, Hansmann ML, Hallek  M,  Prinz  M, Siebert  R, Deckert M: Analysis of Driver Mutational Hot Spots in Blood-Derived Cell-Free DNA of Patients with Primary Central Nervous System Lymphoma Obtained before Intracerebral Biops. Acta Neuropathol 8(1),119 (2020).

Spittau B, Dokalis N, Prinz M: The Role of TGFβ Signaling in Microglia Maturation and Activation. Trends Immunol 41(9), 836-848 (2020).

Mezö C, Dokalis N, Mossad O, Staszewski O, Neuber J, Yilmaz B, Schnepf D, Gomez de Agüero M, Ganal-Vonarbung SC, Macpherson AJ, Meyer-Luehmann M, Staeheli P, Blank T, Prinz M, Erny D: Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimers’s disease. Acta Neuropathologia Communications 8, 119 (2020).

Dersch R, Tebartz van Elst L, Hochstuhl B, Fiebich BL, Stich O, Robinson T, Matysik M, Michel M, Runge K, Nickel K, Domschke K and Endres D: Anti-Thyroid Peroxidase and Anti-Thyroglobulin Autoantibodies in the Cerebrospinal Fluid of Patients with Unipolar Depression. J Clin Med 9(8), 2391 (2020).

Saggio ML, Crisp D, Scott JM, Karoly P, Kuhlmann L, Nakatani M, Murai T, Dümpelmann M, Schulze-Bonhage A, Ikeda A, Cook M, Gliske SV, Lin J, Bernard C, Jirsa V, and Stacey WC: A taxonomy of seizure dynamotyp. eLife 9, e55632; doi: 10.7554/eLife.55632 (2020).

Sheikh BN, Guhathakurta S, Tsang TH, Schwabenland M, Renschler G, Herquel B, Bhardwaj V, Holz H, Stehle T, Bondareva O, Aizarani N, Mossad O, Kretz O, Reichardt W, Chatterjee A, Braun LJ, Thevenon J, Sartelet H, Blank T, Grün D, von Elverfeldt D, Huber TB, Vestweber D, Avilov S, Prinz M, Buescher JM, Akhtar A: Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nature Cell Biology 22, 828-841 (2020).

Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, d´Errico P, Snaidero N, Jordão MJC, Böttcher C, Kierdorf K, Jung S, Priller J, Misgeld T, Vlachos A, Meyer Luehmann M, Knobeloch KP and Prinz M: Novel Hexb-based tools for studying microglia in the CNS. Nat Immunol 21, 802–815 (2020).

Kollert L, Schiele MA, Thiel C, Menke A, Deckert J, Domschke K: DNA hypomethylation of the Krüppel-like factor 11 (KLF11) gene promoter – a putative biomarker of depression comorbidity in panic disorder and of non-anxious depression? J Neural Transm 127, 1539-1546 (in print, 2020).

Göbel-Guéniot K, Gerlach J, Kamberger R, Leupold J, von Elverfeldt D, Hennig J, Korvink JG, Haas CA, LeVan P: Histological correlates of diffusion-weighted magnetic resonance microscopy in a mouse model of mesial temporal lobe epilepsy. Front Neurosci 14, 543, doi: 10.3389/fnins.2020.00543 (2020).

Gray de Cristoforis A, Ferrari F, Clotman F and Vogel T: Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. Molecular Brain 13, 85 (2020).

Berking A-C, Christiane Thiel  C, Schiele  MA, Baumann C, Kalisch  R, Notzen S, Zwanzger  P, Pané-Farré CA,  Hamm A, Alpers GW, Fydrich T, Fehm L, Gerlach AL, Straube B, Kircher T, Rief W, Plag J, Ströhle A, Lang T,  Wittchen H-U, Arolt V, Romanos M, Pauli P, Reif A, Deckert J, Domschke K, Weber H: An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes. J Neural Transm 127, 1527-1537 (2020).

Hille L, Lenz M, Vlachos A, Grüning B, Hein L, Neumann FJ, Nührenberg TG, Trenk D: Ultrastructural, transcriptional, and functional differences between human reticulated and non-reticulated platelets. J Thromb Haemost 18, 2034-2046 (2020).

Keller CW, Kotur MB, Mundt S, Dokalis N, Ligeon LA, Shah AM, Prinz M, Becher B, Münz C, Lünemann JD: CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation. Autophagy, 21(7), 802-815 (2020).

Endres D, Prüss H, Rauer S, Süß P, Venhoff N, Feige B, Schweizer T, Nickel K, Maier S, Egger K, Domschke K, Meyer PT, Tebartz van Elst L: Probable Autoimmune Catatonia With Antibodies Against Cilia on Hippocampal Granule Cells and Highly Suspicious Cerebral FDG-Positron Emission Tomography Findings. Biological Psychiatry 87(9), e29-e31 (2020).

Amann L, Prinz M: The origin, fate and function of macrophages in the peripheral nervous system – an update. In Immunol  32(11), 709-717 (2020).

Schiele MA, Herzog K, Kollert L, Schartner C, Leehr EJ, Böhnlein J, Repple J, Rosenkranz K, Lonsdorf TB, Dannlowski U, Zwanzger D, Reif A, Pauli P, Deckert J, Domschke K: Extending the vulnerability-stress model of mental disorders: A three-dimensional NPSR1 gene x environment x coping interaction study in anxiety. Br J Psychiatry; doi: 10.1192/bjp.2020.73 (in print, 2020)

Ydens E, Amann L, Asselbergh B, Scott CL, Martens L, Sichien D, Mossad O, Blank T, De Prijck D, Low D, Masuda T, Saeys Y, Timmerman V, Stumm R, Ginhoux F, Prinz M, Janssens S and Guilliams M: Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury. Nature Neuroscience 23, 676–689 (2020).

Schiele MA, Gottschalk MG, Domschke K: The applied implications of epigenetics in anxiety, affective and stress-related disorders – focus on psychosocial stress, psychotherapy and prevention. Clin Psychol Rev 77, 101830 (2020).

Süß P, Hoffmann A, Rothe T, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Krönke G, Glass CK, Winkler J, Schlachetzki: Chronic peripheral inflammation causes a region-specific myeloid response in the central nervous system. Cell Rep, 30(12), 4082-4095.e6 (2020).

Friedrich SK, Schmitz R, Bergerhausen M, Lang J, Cham LB, Duhan V, Häussinger D, Hardt C, Addo M, Prinz M, Asano K, Lang PA, Lang KS: Usp18 expression in CD169+ macrophages is important for strong immune response after vaccination with VSV-EBOV. Vaccines, 8(1), 142 (2020).

Duscha A, Gisevius B, Hirschberg S, Yissachar N, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Träger P, Zaiss MM, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, Haghikia A: Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism. Cell,  180(6),1067-1080.e16 8 (2020).

Galanis C, Vlachos A: Hebbian and homeostatic synaptic plasticity – do alterations of one reflect enhancement of the other? Front Cell Neurosci 14, 50; doi: 10.3389/fncel.2020.00050 (2020).

Erny D, Prinz M: How microbiota shape microglial phenotypes and epigenetics. Glia 68(8), 1655-1672. doi: 10.1002/glia.23822 (2020).

Boeck M, Thien A, Wolf J, Hagemeyer N, Laich Y, Yusuf D, Backofen R, Zhang P, Boneva S, Stahl A, Hilgendorf I, Agostini H, Prinz M, Wieghofer P, Schlunck G, Schlecht A, Lange C: Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model. Glia, 68(9):1859-1873 (2020).

Schiele MA, Thiel C, Deckert J, Zaudig M, Berberich G, Domschke K: Monoamine oxidase A hypomethylation in obsessive-compulsive disorder – reversibility by successful psychotherapy? Int J Neuropsychopharmacol 23, 319-23 (2020).

Hou P-S, Ó hAilín D, Vogel T and Hanashima C: Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders. Front Cell Neurosci 14, 35 (2020).

Wang F, Hennig J, LeVan P: Time-domain principal component reconstruction (tPCR): A more efficient and stable iterative reconstruction framework for non-Cartesian functional MRI. Magn Reson Med 00:1-15; doi: 10.1002/mrm.28208 (2020).

Masuda T, Sankowski R, Staszewski O, Prinz M: Microglia heterogeneity in the single-cell era. Cell Rep 30(5), 1271-1281 (2020).

Pous L , Deshpande SS , Nath S , Mezey S , Malik SC , Schildge S, Bohrer C , Topp K , Pfeifer D , Fernández-Klett F, Doostkam S, Galanakis DK , Taylor V , Akassoglou K , Schachtrup C: Fibrinogen Induces Neural Stem Cell Differentiation Into Astrocytes in the Subventricular Zone via BMP Signaling. Nat Commun 11(1), 630, doi: 10.1038/s41467-020-14466-y (2020).

Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, Gyoergy A, Groß O, Siekhaus DE, Dionne MS: Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila. eLife 9, e51595; doi: https://doi.org/10.7554/eLife.51595 (2020).

 

Wallach T, Wetzel M, Dembny P, Staszewski O, Krüger C, Buonfiglioli A, Prinz M, Lehnardt S: Identification of CNS injury-related microRNAs as novel Toll-like Receptor 7/8 signaling ctivators by Small RNA Sequencing. Cells 9(1), pii: E186 (2020).

Delev D, Daka K, Heynckes S, Gaebelein A, Franco P, Pfeifer D, Prinz M, Schnell O, Urbach H, Mader I, Beck J, Grote A, Becker AJ, Heiland DH: Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course. Sci Rep, 2020, 10(1), 96.

Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, Müller SA, Lichtenthaler SF: Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. FASEB J; doi: 10.1096/fj.201902347R (2019).

Donkels C, Peters M, Fariña Núñez MT, Nakagawa JM, Kirsch M, Vlachos A, Scheiwe C, Schulze-Bonhage A, Prinz M, Beck J, Haas CA: Oligodendrocyte lineage and myelination are compromised in the gray matter of focal cortical dysplasia type IIa. Epilepsia; doi: 10.1111/epi.16415 (2019).

Sankowski R, Strohl JJ, Huerta TS, Nasiri E, Mazzarello AN, D’Abramo C, Cheng KF, Staszewski O, Prinz M, Huerta PT, and Al-Abed Y: Endogenous retroviruses are associated with hippocampus-based memory impairment. PNAS 116 (51) 25982-25990; doi.org/10.1073/pnas.182216411 (2019).

R Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R: Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J Clin Invest, pii: 130272; doi: 10.1172/JCI130272 (2019).

Geirsdottir L, David E, Keren-Shaul H, Weiner A, Bohlen SC, Neuber J, Balic A, Giladi A, Sheban F, Dutertre CA, Pfeifle C, Peri F, Raffo-Romero A, Vizioli J, Matiasek K, Scheiwe C, Meckel S, Mätz-Rensing K, van der Meer F, Thormodsson FR, Stadelmann C, Zilkha N, Kimchi T, Ginhoux F, Ulitsky I, Erny D, Amit I, Prinz M: Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell 179(7), 1609-1622.e16; doi: 10.1016/j.cell.2019.11.010 (2019).

Schiele MA, Herzog K, Kollert L, Böhnlein J, Repple J, Rosenkranz K, Leehr EJ, Ziegler C, Lüken U, Dannlowski U, Pauli P, Arolt V, Zwanzger P, Deckert J, Erfurth A, Domschke K: Affective temperaments (TEMPS-A) in panic disorder and healthy probands – genetic modulation by 5-HTT variation. World J Biol Psychiatry; doi: 10.1080/15622975.2019.1705999 (in print, 2020).

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